The city of Los Angeles, California, currently has 18 active clinical trials seeking participants for Depression research studies.
Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD
Recruiting
Efficacy, Safety, and Tolerability of a single administration of COMP360 in participants with treatment-resistant depression (TRD)
Gender:
All
Ages:
18 years and above
Trial Updated:
06/21/2024
Locations: California Center for Psychedelic Therapy, Los Angeles, California +2 locations
Conditions: Treatment Resistant Depression
Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression
Recruiting
Despite the prevalence and significant public health concern over depression among adolescents, up to 40% of depressed adolescents do not respond to first-line antidepressants (herein termed treatment non-response, TNR). The goal of this project is to recruit and assess 160 treatment-seeking depressed adolescents and test whether acute stress impacts peripheral levels of inflammation and downstream levels of glutamate in corticolimbic regions previously associated with depression, whether these... Read More
Gender:
All
Ages:
Between 14 years and 21 years
Trial Updated:
05/17/2024
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Depression in Adolescence
Cognitive Behavioral Immersion: A Randomized Control Trial of Peer-Based Coaching in the Metaverse
Recruiting
This study will test a new cognitive-behavioral skills training program (CBI) delivered in the metaverse. Although initial evidence suggested CBI was feasible for individuals experiencing depression or anxiety, CBI's effectiveness compared to no intervention has yet to be determined. The intervention may be delivered through virtual reality as well as flat-screen devices, such as a computer, which may also affect CBI's effectiveness. The study will enroll up to 306 participants with depression.... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/13/2024
Locations: University of Southern California, Los Angeles, California
Conditions: Depression, Anxiety
Virtual Reality-Reward Training for Anhedonia
Recruiting
The purpose of this study is to compare the effects of Virtual Reality-Reward Training (VR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms. VR-Reward Training is a novel intervention aimed at enhancing savoring of positive experiences among individuals with depression and low positive affect through guided imaginal recounting following immersion in positive VR experiences. Target enrollment is 80 male and female part... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/08/2024
Locations: University of California, Los Angeles, Los Angeles, California
Conditions: Positive Affect, Depression
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
Recruiting
We are the missing link in clinical trials, connecting patients and researchers seamlessly and conveniently using a mobile health platform to advance medical research. We make it easy for patients to contribute to research for medical conditions that matter most to them, regardless of their location or ability to travel.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
04/15/2024
Locations: Sanguine Biosciences, Los Angeles, California
Conditions: All Diagnosed Health Conditions, ADD/ADHD, Alopecia Areata, Ankylosing Spondylitis, Asthma, Atopic Dermatitis Eczema, Beta Thalassemia, Bipolar Disorder, Breast Cancer, Celiac Disease, Cervical Cancer, Chronic Inflammatory Demyelinating Polyneuropathy, Chronic Kidney Diseases, Chronic Obstructive Pulmonary Disease, Colon Cancer, Colorectal Cancer, Crohn's Disease, Cystic Fibrosis, Depression, Diabetes Mellitus, Duchenne Muscular Dystrophy, Endometriosis, Epilepsy, Facioscapulohumeral Muscular Dystrophy, G6PD Deficiency, General Anxiety Disorder, Hepatitis B, Hereditary Hemorrhagic Telangiectasia, HIV/AIDS, Human Papilloma Virus, Huntington's Disease, Idiopathic Thrombocytopenic Purpura, Insomnia, Kidney Cancer, Leukemia, Lung Cancer, Lupus Nephritis, Lymphoma, Melanoma, Multiple Myeloma, Multiple Sclerosis, Myositis, Myotonic Dystrophy, Ovarian Cancer, Pancreatic Cancer, Parkinson's Disease, Polycystic Kidney Diseases, Prostate Cancer, Psoriasis, Psoriatic Arthritis, Rosacea, Scleroderma, Sickle Cell Anemia, Sickle Cell Trait, Sjogren's Syndrome, Skin Cancer, Spinal Muscular Atrophy, Systemic Lupus Erythematosus, Thrombotic Thrombocytopenic Purpura, Trisomy 21, Ulcerative Colitis
Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women
Recruiting
Perinatal Mood and Anxiety Disorders (PMADs) encompass a range of mental health disorders that occur during pregnancy and up to one year postpartum. Approximately 13% of women experience PMADs. This rate doubles for those with adverse perinatal outcomes (APO) and triples in Black women. Recent research points to racism as one significant source of these health disparities. Cultural adaptations to improve communication with providers decrease rates of depression in minority patients as well as im... Read More
Gender:
Female
Ages:
Between 18 years and 65 years
Trial Updated:
04/12/2024
Locations: Cedars Sinai, Los Angeles, California
Conditions: Pregnancy Related, Pregnancy Complications, Pregnancy, High Risk, Depression, Depression, Postpartum, Perinatal Depression, Anxiety, Anxiety in Pregnancy, Stress, Psychological, Racism, Discrimination, Racial, Inflammation
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Recruiting
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/11/2024
Locations: Keck Hospital of USC, Los Angeles, California
Conditions: Treatment Resistant Depression
Evaluating Process of Change in Cognitive Behavioral Therapy and Acceptance and Commitment Therapy for Depression
Recruiting
This study will compare two psychological treatments for major depressive disorder (MDD): cognitive-behavioral therapy (CBT) and acceptance and commitment therapy (ACT). Both treatments are well-studied and supported by evidence as effective options for people experiencing depression. These treatments will be delivered in an online group format via Zoom. The study will enroll up to 150 participants with depression. Half of the participants will receive online group CBT and half will receive onl... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/05/2024
Locations: University of Southern California, Los Angeles, California
Conditions: Depression
The Effects of Music Listening on Anxiety and Agitation in People With Mild and Moderate Cognitive Impairment
Recruiting
Advancing age is associated with an increased risk of developing dementia which can lead to a rapid acceleration in both the healthcare costs and caregiver burden. There is a need to develop non-pharmacological and easily accessible modalities of support for the well-being and enhancing quality of life for individuals with dementia. There is evidence that music listening is associated with stress and anxiety reduction in older adults. Here, the investigators aim to assess the effects of music li... Read More
Gender:
All
Ages:
Between 65 years and 85 years
Trial Updated:
11/21/2023
Locations: University of Southern California, Los Angeles, California
Conditions: Anxiety, Agitated Depression
Acceptance and Commitment Therapy (ACT) for Combating the Effects of Race-Related Stress Among Black Adolescents
Recruiting
The current study seeks to build on previous research that demonstrates the efficacy of Acceptance and Commitment Therapy in combating stigma by investigating the feasibility and acceptability of a protocol to support Black adolescents and young adults in coping with race related stress. The study will consist of a small, purposeful, non-randomized sample (N = 30) of clients enrolled into a 10-session Acceptance and Commitment Therapy group. The group will be offered as part of regular clinical... Read More
Gender:
All
Ages:
Between 13 years and 21 years
Trial Updated:
11/03/2023
Locations: Children's Hospital Los Angeles, Los Angeles, California
Conditions: Race-related Stress, Depression, Anxiety, Quality of Life, Stress Reaction
Efficacy of a Multi-level School Intervention for LGBTQ Youth
Recruiting
Efficacy of a Multi-level School Intervention for LGBTQ Youth
Gender:
All
Ages:
Between 12 years and 20 years
Trial Updated:
10/06/2023
Locations: USC Hybrid High School, Los Angeles, California +2 locations
Conditions: Depression, Anxiety, Post Traumatic Stress Disorder, Coping Behavior, Sexual Minority Stress, Suicidality, Substance Use, Bullying, Harassment
New Moms Mood Tracking & Wellbeing
Recruiting
New moms can be at risk for perinatal depression (PND). The New Moms Mood Tracking and Wellbeing study is investigating mood changes, risk factors for depression and anxiety and treatment response around the time of delivery. Participants will be asked to complete three sets of online surveys between week 28 gestation and week 20 after delivery, in addition to downloading an app to collect data using their smartphone sensors and brief symptom surveys every other week. Women with elevated symptom... Read More
Gender:
Female
Ages:
Between 18 years and 65 years
Trial Updated:
06/21/2023
Locations: University of California, Los Angeles (UCLA), Los Angeles, California
Conditions: Depression, Perinatal Depression, Anxiety, Pregnancy Related